Scaffold Generator is an open-source library that allows for the creation, handling, and display of molecular scaffolds, scaffold trees, and scaffold networks. This is based on the Chemistry Development Kit (CDK) and highly customisable through multiple settings, e.g. five different structural framework definitions are available.
Schaub, J., Zander, J., Zielesny, A. et al. Scaffold Generator: a Java library implementing molecular scaffold functionalities in the Chemistry Development Kit (CDK). J Cheminform 14, 79 (2022). https://doi.org/10.1186/s13321-022-00656-x